Support Material
Resource Library
The kbDNA Resource Library provides even more knowledge helping to bridge the gap between research labs and the manufacturing world. As part of our effort to enable the research, we have found reference material to be an important tool for scientists. Our library of E-Books and Reference materials have been carefully researched, and we have published them here so our researchers can benefit from instant, free access.
Examples of bioconjugation based hybrid molecules include protein structure elucidation using tags, enzyme immobilization, antibodies binding to fluorophores, cellular imaging, microarrays, etc.
Microarray is a versatile and high-throughput method to explore genome and parallel genes data sets with unpredictable functions & variety of samples. After kb original protocol, this version dives deeper into the newer experiment challenges and provides an updated copy to help your experiments
Gain insight on handling the small units of functional antibodies and their antigen-binding activities. In various expression models, kbDNA's protocol provides a quick guide related to the main aspects of scFv cloning methodology
Along with an extensive selection of base-carrying phosphoramidites, our DNA synthesis toolbox includes; standard and mild 3’ base protection options with a variety of CPG supports, functional backbone modifications, duplex stabilizers and more. These compounds allow our synthesis to pursue challenging techniques such as 5’->3’ synthesis and heavy reinforcements to the nucleotides. Additional in-house compounds are categorized into their respective applications. Most notably chain termination for PCR/Sequence Utility, structural studies, DNA mutagenesis/repair, diagnostics, and therapeutics.
Modifying DNA during synthesis involves a bit of creativity along with untraditional chemistry throughout the synthesis workflow. Different classes of modifiers have grown over time, but the most tried and true begins with 3’ or 5’ amino modifiers and the use of spacers and “branching” modifications. This paved the way for introducing more elaborate modifiers into sequences, such as compounded functional groups and a wide array of labels.
Post-translational modifications are extensive and challenging to study. We focus on 10 key chemistries
Find your protein of interest using our novel catalog method. This guide offers an updated catalog on recombinant expression technology and features kbDNA's in-vivo protein products including key analytes for the following libraries: Biomarkers, Immune-targets,Hormones,Heat Shock,Cytokines,Infectious Disease,Glycobiology, Assay Proteins, biosimilars
Download the building blocks table as both a reference sheet and catalog for our phospho-amidite reagents data. This includes an array of backbone & base modifications for:
Antisense RNA/RNAi
Cellular uptake
Fluorescent dyes
Affinity labels
Degenerative (mixed) sets
Characterization of Multi-Protein Complexes (MPCs) by BN-PAGE
As the application of oligonucleotides continues to grow in research, advancements in nucleic acid chemistry are expanding manufacturing capabilities-particularly with RNA. Key innovations have optimized traditional synthesis with automation and specialty compounds to help deliver versatile-stable and pure RNA tools to support discovery analysis and solutions for therapeutic designs.
In this eBook, we delve deeper into the building block reagents, modifications and technologies guiding the way for versatile synthesis of RNA.
