Proteases
Chitotriosidase
Recombinant ID:
3915
Gene of Interest
Gene Synonyms:
CHIT1
Protein Names:
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
51681
Length (aa):
466
Proteomics (Proteome ID):
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Proteomics (Chromosome):
UP000005640
Sequence:
MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
Analysis Summary:
Active site (1); Alternative sequence (4); Beta strand (22); Binding site (2); Chain (1); Disulfide bond (3); Domain (1); Erroneous initiation (1); Glycosylation (1); Helix (17); Natural variant (5); Region (3); Signal peptide (1); Turn (6),Very high plasma levels of CHIT1 are found in patients with Gaucher disease type 1 (GD I). Can be used as diagnostic aid and to evaluate the success of treatment that brings levels back to normal.,N/A,Detected in spleen. Secreted by cultured macrophages. {ECO:0000269|PubMed:7836450}.,N/A,N/A,N/A,N/A
Reagent Data
Name:
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Subcategory:
Recombinant
Molecular Weight:
51.3 kDa
Source:
HEK293
Species:
Human
Tag:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Purity:
> 98%
Determined:
SDS-PAGE
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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