Biomarkers
Carboxypeptidase A4
Recombinant ID:
3908
Gene of Interest
Gene Synonyms:
CPA4;CPA3;UNQ694/PRO1339
Protein Names:
Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
47351
Length (aa):
421
Metal Binding:
METAL 181 181 Zinc; catalytic. {ECO:0000269|PubMed:22294694}.; METAL 184 184 Zinc; catalytic. {ECO:0000269|PubMed:22294694}.; METAL 308 308 Zinc; catalytic. {ECO:0000269|PubMed:22294694}.
Proteomics (Proteome ID):
Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
N/A
Sequence:
MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY
Function [CC]:
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). {ECO:0000269|PubMed:10383164, ECO:0000269|PubMed:20385563}.
Analysis Summary:
Active site (1); Alternative sequence (1); Beta strand (18); Binding site (2); Chain (1); Disulfide bond (1); Glycosylation (1); Helix (17); Metal binding (3); Natural variant (4); Propeptide (1); Region (4); Sequence conflict (1); Signal peptide (1); Turn (4); Up-regulated by inhibitors of histone dacetylation. {ECO:0000269|PubMed:10383164}.; Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
Reagent Data
Name:
Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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