Immune Path
CD47
Recombinant ID:
3770
Gene of Interest
Gene Synonyms:
Cd47
Protein Names:
Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)
Accession Data
Organism:
Rattus norvegicus (Rat)
Mass (kDa):
32995
Length (aa):
303
Proteomics (Proteome ID):
Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)
Proteomics (Chromosome):
UP000002494
Sequence:
MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN
Function [CC]:
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus. {ECO:0000250, ECO:0000269|PubMed:9592107}.
Reagent Data
Name:
Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)
Subcategory:
Recombinant
Molecular Weight:
40.4 kDa
Source:
HEK293
Species:
Tag:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Purity:
> 98%
Determined:
SDS-PAGE
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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