BCMA
Human Recombinant TNFRSF17 - Fc Tagged
Reference ID:KB-3665
Western Blot
ELISA
FACS
Protein:Protein
Flow Cytometry
Gene of Interest
Gene Synonyms:TNFRSF17;BCM;BCMA
Protein Names:Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Accession Data
Organism:Homo sapiens (Human)
Mass (kDa):201.65
Length (aa):184
Sequence:MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR
Proteomics (Proteome ID):UP000005640
Proteomics (Chromosome): Chromosome 16
Function [CC]:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
Site:SITE 3 4 Breakpoint for translocation to form IL2/TNFRSF17 oncogene.
Tissue Specificity:Expressed in mature B-cells, but not in T-cells or monocytes.
Disease:Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. {ECO:0000269|PubMed:1396583}.
Reagent Data
Name:BCMA
Class:Fluorecent Labeled
Subcategory:Protein
Region:Met 1 - Ala 54
Molecular Weight:32
Source:HEK293
Species:Human
Tag:Fc
Conjugation:FITC
Format:Lyophilized
Purification System:Chromatography
Formulation:Sterile-filtered colorless solution
Formulation Concentration:1 mg/ml
Buffer Volume:Standard
Buffer Solution:PBS
pH:7.4-7.5
Toxicity
Endotoxin Level:< 1%
Aggregate Tested By:SDS-PAGE
Endotoxin Screened:< 0.1 ng/ug
Purity:> 98%
Determined: SDS-PAGE
Stain:Blue
Chromotography:Anion-exchange
Validated: RP-HPLC
Sample Handling
Storage:-20°C
Stability:This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:Reconstitute in sterile distilled H2O to no less than 100 ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.