Cytokines
VEGF164
Recombinant ID:
3643
Gene of Interest
Gene Synonyms:
Vegfa;Vegf
Protein Names:
Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
Accession Data
Organism:
Mus musculus (Mouse)
Mass (kDa):
25283
Length (aa):
214
Proteomics (Proteome ID):
Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
Proteomics (Chromosome):
UP000000589
Sequence:
MNFLLSWVHWTLALLLYLHHAKWSQAAPTTEGEQKSHEVIKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNITMQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKKSVRGKGKGQKRKRKKSRFKSWSVHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Analysis Summary:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). {ECO:0000250, ECO:0000269|PubMed:26503042}.,Alternative sequence (8); Chain (1); Disulfide bond (5); Erroneous initiation (1); Glycosylation (1); Sequence conflict (2); Signal peptide (1),By IL-6 and FSH in vitro. {ECO:0000269|PubMed:16259067}.,In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression of VEGF continues in kidney glomeruli and choroid plexus in adults.
Reagent Data
Name:
Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
Subcategory:
Recombinant
Amino Acid Sequence:
Inquire
Species
Mouse
Tag:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Buffer Volume
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Purity:
> 98%
Determined:
SDS-PAGE
Stained:
Inquire
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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