Biomarkers
FOLR1
Recombinant ID:
3349
Gene of Interest
Gene Synonyms:
Folr1;Fbp1;Folbp1
Protein Names:
Folate receptor alpha (FR-alpha) (Folate receptor 1) (Folate-binding protein 1)
Accession Data
Organism:
Mus musculus (Mouse)
Mass (kDa):
29449
Length (aa):
255
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Folate receptor alpha (FR-alpha) (Folate receptor 1) (Folate-binding protein 1)
Proteomics (Chromosome):
UP000000589
Disease:
N/A
Mutagenesis:
N/A
Sequence:
MAHLMTVQLLLLVMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDNLHDQCSPWKTNSCCSTNTSQEAHKDISYLYRFNWNHCGTMTSECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERILDVPLCKEDCQQWWEDCQSSFTCKSNWHKGWNWSSGHNECPVGASCHPFTFYFPTSAALCEEIWSHSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEAMSGAGFHGTWPLLCSLSLVLLWVIS
Function [CC]:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. {ECO:0000269|PubMed:10508523, ECO:0000269|PubMed:12854656, ECO:0000269|PubMed:15259034, ECO:0000269|PubMed:15703271, ECO:0000269|PubMed:17286298, ECO:0000269|PubMed:1894617}.
Analysis Summary:
Binding site (3); Chain (1); Disulfide bond (8); Glycosylation (3); Lipidation (1); Propeptide (1); Region (2); Sequence conflict (1); Signal peptide (1); Detected in kidney proximal tubules (at protein level). {ECO:0000269|PubMed:15703271}.
Reagent Data
Name:
Folate receptor alpha (FR-alpha) (Folate receptor 1) (Folate-binding protein 1)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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