Biomarkers
E-Selectin
Recombinant ID:
3304
Gene of Interest
Gene Synonyms:
SELE;ELAM1
Protein Names:
E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
66655
Length (aa):
610
Metal Binding:
METAL 101 101 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:26117840}.; METAL 103 103 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:1G1T, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.; METAL 109 109 Calcium. {ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.; METAL 126 126 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:1G1T, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.; METAL 127 127 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:1G1T, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.
Proteomics (Proteome ID):
E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
MUTAGEN 109 109 E->D: Decreased adhesion to cells expressing SELPLG. {ECO:0000269|PubMed:28011641}.
Sequence:
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL
Function [CC]:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848, ECO:0000269|PubMed:28011641}.
Analysis Summary:
Beta strand (25); Chain (1); Disulfide bond (19); Domain (8); Glycosylation (11); Helix (3); Metal binding (5); Mutagenesis (1); Natural variant (11); Region (3); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (2)
Reagent Data
Name:
E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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