Biomarkers

Dkk-1

Recombinant ID:

3290

Gene of Interest

Gene Synonyms:

DKK1;UNQ492/PRO1008

Protein Names:

Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)

Accession Data

Organism:

Homo sapiens (Human)

Mass (kDa):

28672

Length (aa):

266

Metal Binding:

Pending Verification

Proteomics (Proteome ID):

Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)

Proteomics (Chromosome):

UP000005640

Disease:

N/A

Mutagenesis:

N/A

Sequence:

MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH

Function [CC]:

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). {ECO:0000250|UniProtKB:O54908, ECO:0000269|PubMed:22000856, ECO:0000303|PubMed:17143291}.

Analysis Summary:

Beta strand (5); Chain (1); Disulfide bond (10); Glycosylation (2); Helix (2); Region (2); Signal peptide (1); Placenta.

Reagent Data

Name:

Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)

Subcategory:

Recombinant

Source:

HEK293

Species:

Format:

Lyophilized

pH:

7.4-7.5

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

Metal Chelating Agents

Determined:

SDS-PAGE

Purity:

> 98%

Validated:

RP-HPLC

Sample Handling

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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