Biomarkers
Cystatin SN
Recombinant ID:
3286
Gene of Interest
Gene Synonyms:
CST1
Protein Names:
Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
16388
Length (aa):
141
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
N/A
Sequence:
MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES
Function [CC]:
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
Analysis Summary:
Chain (1); Disulfide bond (2); Mass spectrometry (2); Motif (1); Natural variant (5); Signal peptide (1); Site (1); Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}.
Reagent Data
Name:
Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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