Biomarkers
CEACAM-8
Recombinant ID:
3274
Gene of Interest
Gene Synonyms:
CEACAM8;CGM6
Protein Names:
Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
38154
Length (aa):
349
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
MUTAGEN 40 45 AVPSNA->STPFNV: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 61 63 DPR->NRI: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 66 66 N->S: Inhibits heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 72 75 TVDA->RVDG: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 78 78 R->A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6. {ECO:0000269|PubMed:26483485}.; MUTAGEN 78 78 R->Q: Inhibits heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 85 89 SNQQI->GTQQA: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 97 97 N->G: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 123 123 Q->A: Does not affect the monomeric structure. Decreases heterodimerization with CEACAM6. {ECO:0000269|PubMed:26483485}.; MUTAGEN 129 129 L->A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6. {ECO:0000269|PubMed:26483485}.
Sequence:
MGPISAPSCRWRIPWQGLLLTASLFTFWNPPTTAQLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDALVQGSSPGLSARATVSIMIGVLARVALI
Function [CC]:
Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). {ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:8776764}.
Analysis Summary:
Beta strand (9); Chain (1); Disulfide bond (2); Domain (3); Glycosylation (11); Helix (2); Lipidation (1); Mutagenesis (10); Natural variant (5); Propeptide (1); Signal peptide (1); Turn (2); Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
Reagent Data
Name:
Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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