Biomarkers

CD2

Recombinant ID:

3221

Gene of Interest

Gene Synonyms:

CD2;SRBC

Protein Names:

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Accession Data

Organism:

Homo sapiens (Human)

Mass (kDa):

39448

Length (aa):

351

Metal Binding:

Pending Verification

Proteomics (Proteome ID):

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Proteomics (Chromosome):

UP000005640

Disease:

N/A

Mutagenesis:

MUTAGEN 67 67 K->R: Loss of CD58 binding. {ECO:0000269|PubMed:2444890}.; MUTAGEN 70 70 Q->K: Loss of CD58 binding. {ECO:0000269|PubMed:2444890}.; MUTAGEN 110 110 Y->D: Loss of CD58 and CD59 binding. {ECO:0000269|PubMed:2444890}.; MUTAGEN 111 111 D->H: Loss of CD58 and CD59 binding. {ECO:0000269|PubMed:2444890}.

Sequence:

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN

Function [CC]:

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Analysis Summary:

Beta strand (16); Chain (1); Compositional bias (1); Disulfide bond (2); Domain (2); Glycosylation (3); Helix (3); Mutagenesis (4); Natural variant (3); Region (2); Sequence conflict (2); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (2)

Reagent Data

Name:

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Subcategory:

Recombinant

Source:

HEK293

Species:

Format:

Lyophilized

pH:

7.4-7.5

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

Metal Chelating Agents

Determined:

SDS-PAGE

Purity:

> 98%

Validated:

RP-HPLC

Sample Handling

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Share by: