Biomarkers

C-Reactive Protein

Recombinant ID:

3198

Gene of Interest

Gene Synonyms:

CRP;PTX1

Protein Names:

C-reactive protein [Cleaved into: C-reactive protein(1-205)]

Accession Data

Organism:

Homo sapiens (Human)

Mass (kDa):

25039

Length (aa):

224

Metal Binding:

METAL 78 78 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 79 79 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 156 156 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 156 156 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 157 157 Calcium 1; via carbonyl oxygen. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 158 158 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 158 158 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 168 168 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.

Proteomics (Proteome ID):

C-reactive protein [Cleaved into: C-reactive protein(1-205)]

Proteomics (Chromosome):

UP000005640

Disease:

N/A

Mutagenesis:

N/A

Sequence:

MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP

Function [CC]:

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Analysis Summary:

Active site (1); Alternative sequence (8); Beta strand (21); Binding site (1); Chain (1); Disulfide bond (6); Domain (5); Glycosylation (11); Helix (17); Modified residue (5); Natural variant (11); Nucleotide binding (1); Region (1); Repeat (2); Signal peptide (1); Site (3); Topological domain (2); Transmembrane (1); Turn (4); Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.; Widely expressed in fetal brain. {ECO:0000269|PubMed:7936202}.; Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain. {ECO:0000269|PubMed:11798182, ECO:0000269|PubMed:7936202}.

Reagent Data

Name:

C-reactive protein [Cleaved into: C-reactive protein(1-205)]

Subcategory:

Recombinant

Source:

HEK293

Species:

Format:

Lyophilized

pH:

7.4-7.5

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

Metal Chelating Agents

Determined:

SDS-PAGE

Purity:

> 98%

Validated:

RP-HPLC

Sample Handling

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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