Biomarkers
BCMA
Recombinant ID:
3190
Gene of Interest
Gene Synonyms:
TNFRSF17;BCM;BCMA
Protein Names:
Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
20165
Length (aa):
184
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Proteomics (Chromosome):
UP000005640
Disease:
Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. {ECO:0000269|PubMed:1396583}.
Mutagenesis:
N/A
Sequence:
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR
Function [CC]:
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
Analysis Summary:
Alternative sequence (1); Beta strand (3); Chain (1); Disulfide bond (3); Helix (2); Natural variant (7); Repeat (1); Site (1); Topological domain (2); Transmembrane (1); Turn (3); Expressed in mature B-cells, but not in T-cells or monocytes.
Reagent Data
Name:
Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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