Biomarkers
BAFFR
Recombinant ID:
3188
Gene of Interest
Gene Synonyms:
Tnfrsf13c;Baffr;Bcmd;Br3
Protein Names:
Tumor necrosis factor receptor superfamily member 13C (B-cell maturation defect) (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)
Accession Data
Organism:
Mus musculus (Mouse)
Mass (kDa):
18798
Length (aa):
175
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Tumor necrosis factor receptor superfamily member 13C (B-cell maturation defect) (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)
Proteomics (Chromosome):
UP000000589
Disease:
Note=Defects in Tnfrsf13c are a cause of severe B-cell deficiency. B-cell deficient strain A/WySnJ has a 4.7 kb insertion in the BAFFR gene leading to an altered C-terminus. The mutant RNA is not detectable. B-cell lymphopoiesis is normal, but the life span of peripheral B-cells is much reduced. {ECO:0000269|PubMed:11591325}.
Mutagenesis:
N/A
Sequence:
MGARRLRVRSQRSRDSSVPTQCNQTECFDPLVRNCVSCELFHTPDTGHTSSLEPGTALQPQEGSALRPDVALLVGAPALLGLILALTLVGLVSLVSWRWRQQLRTASPDTSEGVQQESLENVFVPSSETPHASAPTWPPLKEDADSALPRHSVPVPATELGSTELVTTKTAGPEQ
Function [CC]:
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11747827}.
Analysis Summary:
Alternative sequence (1); Chain (1); Disulfide bond (2); Glycosylation (1); Region (1); Repeat (1); Topological domain (2); Transmembrane (1); Highly expressed in spleen and testis; detected at lower levels in lung and thymus.
Reagent Data
Name:
Tumor necrosis factor receptor superfamily member 13C (B-cell maturation defect) (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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