Cytokines
CCL2, biotinylated
Recombinant ID:
1649
Gene of Interest
Gene Synonyms:
CCL2;MCP1;SCYA2
Protein Names:
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
11025
Length (aa):
99
Proteomics (Proteome ID):
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Proteomics (Chromosome):
UP000005640
Sequence:
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
Analysis Summary:
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). {ECO:0000269|PubMed:10529171, ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:8107690, ECO:0000269|PubMed:8195247, ECO:0000269|PubMed:8627182, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}.,Beta strand (7); Chain (1); Disulfide bond (2); Glycosylation (1); Helix (3); Modified residue (1); Mutagenesis (22); Signal peptide (1); Site (10),Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712). {ECO:0000269|PubMed:23233732, ECO:0000269|PubMed:23955712}.,Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477). {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2513477}.
Reagent Data
Name:
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Subcategory:
Recombinant
Amino Acid Sequence:
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAK EICADPKQKWVQDSIDHLDKQTQTPKT
Species
Human
Tag:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered and lyophilized
Buffer Volume
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Purity:
> 97%
Determined:
SDS-PAGE
Stained:
Migration Assay
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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