Secreted Hormones and Proteins
Cardiac Troponin C
Recombinant ID:
1591
Gene of Interest
Gene Synonyms:
TNNC1;TNNC
Protein Names:
Troponin C, slow skeletal and cardiac muscles (TN-C)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
18403
Length (aa):
161
Proteomics (Proteome ID):
Troponin C, slow skeletal and cardiac muscles (TN-C)
Proteomics (Chromosome):
UP000005640
Sequence:
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Disease:
Cardiomyopathy, dilated 1Z (CMD1Z) [MIM:611879]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269|PubMed:15542288}. Note=The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, familial hypertrophic 13 (CMH13) [MIM:613243]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:11385718, ECO:0000269|PubMed:16302972, ECO:0000269|PubMed:18572189, ECO:0000269|PubMed:19439414}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function [CC]:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Analysis Summary:
Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
Reagent Data
Name:
Troponin C, slow skeletal and cardiac muscles (TN-C)
Subcategory:
Recombinant
Molecular Weight:
18 kDa
Source:
E.Coli
Species:
Human
Tag:
Format:
Solution
pH:
7
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
10mM
Buffer Solution:
Sodium-phosphate
Metal Stabilizers
NaCl:
150mM
Metal Chelating Agents
Purity:
> 95%
Determined:
SDS-PAGE
Validated:
RP-HPLC
Sample Handling
Storage:
4°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Solution for appropriate storage temperature
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